The Biochemistry of Metabolic Disorders

Overview

Metabolism and metabolic pathways govern every living cell in the body in order for it to function properly. The primary aim of cellular metabolism is to provide energy from intake of food to maintain function and hence, sustain life.

Metabolic processes are, essentially, made up of many interconnected biochemical reaction and cycles that break down nutrients from our food intake and those that build and repair the body. These processes affect many factors including diet, exercise, age, gender, genetics and health conditions.

When metabolic processes and pathways are compromised due to genetic or environmental factors, this may lead to metabolic-related disorders such as cancer, diabetes and heart conditions. Many of these disorders can be prevented or treated and others may need to be managed in order to maintain a healthy and long life. 

In this course, you will be introduced to the major metabolic pathways that break down the various nutrients such as sugars, fats, proteins and carbohydrates from the intake of food and how they are converted to energy and other molecules that maintain the cells' function in order to respond favourably, in spite of their immediate environmental surrounding, and sustain life. This can be done through cellular growth and cell division. The course will also discuss how metabolic disorders may arise and how they may be managed, prevented or treated.

Programme details

Course starts: 3 Oct 2024

Week 1: Introduction to Cellular Metabolism

Week 2: Glucose, Glycolysis and Fermentation

Week 3: The Warburg Effect: Glucose and Cancer

Week 4: The Citric Acid Cycle

Week 5: Oxidative Phosphorylation and Energy Production

Week 6: Fatty Acid Oxidation and Lipid Metabolism

Week 7: Pentose Phosphate Pathway

Week 8: Metabolic Disorders

Week 9: Metabolic Diseases and Prevention

Week 10: Workshop: Case Study

Certification

To complete the course and receive a certificate, you will be required to attend at least 80% of the classes on the course and pass your final assignment. Upon successful completion, you will receive a link to download a University of Oxford digital certificate. Information on how to access this digital certificate will be emailed to you after the end of the course. The certificate will show your name, the course title and the dates of the course you attended. You will be able to download your certificate or share it on social media if you choose to do so.

Fees

Description Costs
Course Fee £285.00
Take this course for CATS points £30.00

Funding

If you are in receipt of a UK state benefit, you are a full-time student in the UK or a student on a low income, you may be eligible for a reduction of 50% of tuition fees. Please see the below link for full details:

Concessionary fees for short courses

Tutor

Dr Jaff Jaffar

Jaff is an academic at the Department of Biochemical Engineering at University College London. His main teaching interest are in Biochemistry, Medicinal Chemistry and Gene Therapy. His research interests are in the development and commercialisation of anti-cancer agents.

Course aims

The main objectives are to understand the metabolic processes and how the metabolic-related disorders are caused, and how these disorders may be prevented or treated.

The main aims of the course are:

  • to understand the major cellular metabolic processes
  • how the main nutrients are converted to energy
  • how the energy from metabolism is utilised
  • what are the causes of metabolic disorders
  • how metabolic disorders can be managed, prevented or treated

Teaching methods

In each session, there will be a PowerPoint presentation introducing the topic followed by a question and answer (Q&A) session and discussion between the learners and the tutor. Active participation is encouraged. The case study lecture (in week 10) will be delivered as a workshop in which students will be grouped together to discuss a topic-specific area. In this session, the learners will be encouraged to discuss and present their finding to the rest of the class.

Learning outcomes

By the end of the course, the learner will be able to:

  • Assess and classify the major metabolic processes and pathways and the important biochemical reactions that are involved in maintaining cell function.
  • Identify the key stages of the metabolic processes that can be manipulated to control and regulate metabolism.
  • Recognise how metabolic-related disorders are caused and their consequence to health conditions
  • Gain an understanding of the main metabolic disorders and how they can be prevented, managed and treated.

Assessment methods

The assessment is a written essay (1500 words) on a specific topic-related to this course. The title will be made available at the beginning of the course. The learners will be provided with guidance on how to complete the assignment. The learners will have 2 weeks to complete the assignment (after the course has finished).

Coursework is an integral part of all weekly classes and everyone enrolled will be expected to do coursework in order to benefit fully from the course. Only those who have registered for credit will be awarded CATS points for completing work to the required standard.

Students must submit a completed Declaration of Authorship form at the end of term when submitting your final piece of work. CATS points cannot be awarded without the aforementioned form - Declaration of Authorship form

Application

To earn credit (CATS points) for your course you will need to register and pay an additional £30 fee per course. You can do this by ticking the relevant box at the bottom of the enrolment form or when enrolling online.

Please use the 'Book' or 'Apply' button on this page. Alternatively, please complete an Enrolment Form (Word) or Enrolment Form (Pdf)

Level and demands

This course is suitable for non-specialist students. No prior course knowledge or work is required.

The Department's Weekly Classes are taught at FHEQ Level 4, i.e. first year undergraduate level, and you will be expected to engage in a significant amount of private study in preparation for the classes. This may take the form, for instance, of reading and analysing set texts, responding to questions or tasks, or preparing work to present in class.

Credit Accumulation and Transfer Scheme (CATS)

To earn credit (CATS points) you will need to register and pay an additional £30 fee per course. You can do this by ticking the relevant box at the bottom of the enrolment form or when enrolling online. Students who register for CATS points will receive a Record of CATS points on successful completion of their course assessment.

Students who do not register for CATS points during the enrolment process can either register for CATS points prior to the start of their course or retrospectively from the January 1st after the current full academic year has been completed. If you are enrolled on the Certificate of Higher Education you need to indicate this on the enrolment form but there is no additional registration fee.